Allele-specific expression reveals interactions between genetic variation and environment

Identifying interactions between genetics and the environment (GxE) remains challenging. We have developed EAGLE, a hierarchical Bayesian model for identifying GxE interactions based on association between environment and allele-specific expression (ASE). Combining RNA-sequencing of whole blood and...

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Detalhes bibliográficos
Publicado no:Nat Methods
Main Authors: Knowles, David A., Davis, Joe R., Edgington, Hilary, Raj, Anil, Favé, Marie-Julie, Zhu, Xiaowei, Potash, James B., Weissman, Myrna M., Shi, Jianxin, Levinson, Douglas F., Awadalla, Philip, Mostafavi, Sara, Montgomery, Stephen B., Battle, Alexis
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501199/
https://ncbi.nlm.nih.gov/pubmed/28530654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4298
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