Preclinical Evaluation of the Short-Term Toxicity of 4-(N)-Docosahexaenoyl 2′, 2′-Difluorodeoxycytidine (DHA-dFdC)

PURPOSE: This study was designed to test the short-term toxicity of DHA-dFdC in a mouse model and its efficacy in a mouse model of leukemia at or below its repeat-dose maximum tolerated dose (RD-MTD). METHOD: A repeat-dose dose-ranging toxicity study was designed to determine the tolerability of DHA...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Valdes, Solange, Naguib, Youssef W., Finch, Rick A., Baze, Wallace B., Jolly, Christopher A., Cui, Zhengrong
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488709/
https://ncbi.nlm.nih.gov/pubmed/28352993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2139-x
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