Activation of AMP‐activated protein kinase by metformin ablates angiotensin II‐induced endoplasmic reticulum stress and hypertension in mice in vivo

BACKGROUND AND PURPOSE: Metformin, one of the most frequently prescribed medications for type 2 diabetes, reportedly exerts BP‐lowering effects in patients with diabetes. However, the effects and underlying mechanisms of metformin on BP in non‐diabetic conditions remain to be determined. The aim of...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Duan, Quanlu, Song, Ping, Ding, Ye, Zou, Ming‐Hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5466537/
https://ncbi.nlm.nih.gov/pubmed/28436023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13833
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