Uncoupling genotoxic stress responses from circadian control increases susceptibility to mammary carcinogenesis

We previously demonstrated that chemopreventive methylselenocysteine (MSC) prevents N-Nitroso-N-methylurea (NMU)-induced mammary carcinogenesis in the susceptible Fischer 344 (F344) rats by enhancing NAD(+)-dependent SIRT1 activity, restoring circadian expression of Period 2 (Per2) and circadian con...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Fang, Mingzhu, Ohman Strickland, Pamela A., Kang, Hwan-Goo, Zarbl, Helmut
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464825/
https://ncbi.nlm.nih.gov/pubmed/28427145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15678
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