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P08.26 ATP depletion induced by dual inhibition of ALDH and mitochondrial complex I make therapeutic response in glioblastoma
Introduction: Deprivation of energy metabolism has been emerged as an effective therapeutic approach for various tumors. Cancer cells prefer cytosolic NADH supplied by aldehyde dehydrogenase (ALDH) for ATP production through oxidative phosphorylation (OxPhos). Dual inhibition of ALDH using KN817 and...
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| Pubblicato in: | Neuro Oncol |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5463896/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox036.216 |
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