Antifungal Tc17 cells are durable and stable, persisting as long-lasting vaccine memory without plasticity towards IFNγ cells

Our understanding of persistence and plasticity of IL-17A(+) memory T cells is clouded by conflicting results in models analyzing T helper 17 cells. We studied memory IL-17A(+) CD8(+) T-cell (Tc17) homeostasis, persistence and plasticity during fungal vaccine immunity. We report that vaccine-induced...

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Опубликовано в: :PLoS Pathog
Главные авторы: Nanjappa, Som Gowda, McDermott, Andrew J., Fites, J. Scott, Galles, Kevin, Wüthrich, Marcel, Deepe, George S., Klein, Bruce S.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5456400/
https://ncbi.nlm.nih.gov/pubmed/28542595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006356
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