Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

Mutations in the MEN1 gene are associated with the multiple endocrine neoplasia syndrome type 1 (MEN1), which is characterized by parathyroid hyperplasia and tumors of the pituitary and pancreatic islets. The mechanism by which MEN1 acts as a tumor suppressor is unclear. We have recently shown that...

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Hauptverfasser: Milne, Thomas A., Hughes, Christina M., Lloyd, Ricardo, Yang, Zhaohai, Rozenblatt-Rosen, Orit, Dou, Yali, Schnepp, Robert W., Krankel, Cynthia, LiVolsi, Virginia A., Gibbs, Denise, Hua, Xianxin, Roeder, Robert G., Meyerson, Matthew, Hess, Jay L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2005
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC545577/
https://ncbi.nlm.nih.gov/pubmed/15640349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408836102
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