Inactivation of Pif1 helicase causes a mitochondrial myopathy in mice

Mutations in genes coding for mitochondrial helicases such as TWINKLE and DNA2 are involved in mitochondrial myopathies with mtDNA instability in both human and mouse. We show that inactivation of Pif1, a third member of the mitochondrial helicase family, causes a similar phenotype in mouse. pif1−/−...

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Pubblicato in:Mitochondrion
Autori principali: Bannwarth, Sylvie, Berg-Alonso, Laetitia, Augé, Gaëlle, Fragaki, Konstantina, Kolesar, Jill E., Lespinasse, Françoise, Lacas-Gervais, Sandra, Burel-Vandenbos, Fanny, Villa, Elodie, Belmonte, Frances, Michiels, Jean-François, Ricci, Jean-Ehrland, Gherardi, Romain, Harrington, Lea, Kaufman, Brett A., Paquis-Flucklinger, Véronique
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454384/
https://ncbi.nlm.nih.gov/pubmed/26923168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2016.02.005
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