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Dicer-dependent production of microRNA221 in hepatocytes inhibits p27 and is required for liver regeneration in mice
Dicer processes microRNAs (miRs) into active forms in a wide variety of tissues, including the liver. To determine the role of Dicer in liver regeneration, we performed a series of in vivo and in vitro studies in a murine 2/3 hepatectomy model. Dicer was downregulated after 2/3 hepatectomy, and loss...
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| Gepubliceerd in: | Am J Physiol Gastrointest Liver Physiol |
|---|---|
| Hoofdauteurs: | , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Physiological Society
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5451560/ https://ncbi.nlm.nih.gov/pubmed/28232457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00383.2016 |
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