WCK 5107 (Zidebactam) and WCK 5153 Are Novel Inhibitors of PBP2 Showing Potent “β-Lactam Enhancer” Activity against Pseudomonas aeruginosa, Including Multidrug-Resistant Metallo-β-Lactamase-Producing High-Risk Clones

Zidebactam and WCK 5153 are novel β-lactam enhancers that are bicyclo-acyl hydrazides (BCH), derivatives of the diazabicyclooctane (DBO) scaffold, targeted for the treatment of serious infections caused by highly drug-resistant Gram-negative pathogens. In this study, we determined the penicillin-bin...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Moya, Bartolome, Barcelo, Isabel M., Bhagwat, Sachin, Patel, Mahesh, Bou, German, Papp-Wallace, Krisztina M., Bonomo, Robert A., Oliver, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444176/
https://ncbi.nlm.nih.gov/pubmed/28289035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02529-16
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