MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress

Gaining mechanistic insight into interaction between causative factors of complex multifactorial diseases involving photoreceptor damage might aid in devising effective therapies. Oxidative stress is one of the potential unifying mechanisms for interplay between genetic and environmental factors tha...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nagar, Saumya, Noveral, Sarah M., Trudler, Dorit, Lopez, Kevin M., McKercher, Scott R., Han, Xuemei, Yates, John R., Piña-Crespo, Juan C., Nakanishi, Nobuki, Satoh, Takumi, Okamoto, Shu-ichi, Lipton, Stuart A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441815/
https://ncbi.nlm.nih.gov/pubmed/28461502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613067114
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