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Robust estimation of the expected survival probabilities from high-dimensional Cox models with biomarker-by-treatment interactions in randomized clinical trials

BACKGROUND: Thanks to the advances in genomics and targeted treatments, more and more prediction models based on biomarkers are being developed to predict potential benefit from treatments in a randomized clinical trial. Despite the methodological framework for the development and validation of pred...

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Pubblicato in:BMC Med Res Methodol
Autori principali: Ternès, Nils, Rotolo, Federico, Michiels, Stefan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441049/
https://ncbi.nlm.nih.gov/pubmed/28532387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12874-017-0354-0
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