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Efficient Genome Editing of a Facultative Thermophile Using Mesophilic spCas9

[Image: see text] Well-developed genetic tools for thermophilic microorganisms are scarce, despite their industrial and scientific relevance. Whereas highly efficient CRISPR/Cas9-based genome editing is on the rise in prokaryotes, it has never been employed in a thermophile. Here, we apply Streptoco...

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發表在:ACS Synth Biol
Main Authors: Mougiakos, Ioannis, Bosma, Elleke F., Weenink, Koen, Vossen, Eric, Goijvaerts, Kirsten, van der Oost, John, van Kranenburg, Richard
格式: Artigo
語言:Inglês
出版: American Chemical Society 2017
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440800/
https://ncbi.nlm.nih.gov/pubmed/28146359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.6b00339
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