A Direct Intersection between p53 and Transforming Growth Factor β Pathways Targets Chromatin Modification and Transcription Repression of the α-Fetoprotein Gene

We purified the oncoprotein SnoN and found that it functions as a corepressor of the tumor suppressor p53 in the regulation of the hepatic α-fetoprotein (AFP) tumor marker gene. p53 promotes SnoN and histone deacetylase interaction at an overlapping Smad binding, p53 regulatory element (SBE/p53RE) i...

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Autori principali: Wilkinson, Deepti S., Ogden, Stacey K., Stratton, Sabrina A., Piechan, Julie L., Nguyen, Thi T., Smulian, George A., Barton, Michelle Craig
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC544019/
https://ncbi.nlm.nih.gov/pubmed/15657445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.3.1200-1212.2005
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