A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity

In obesity, white adipose tissue (AT) inflammation is associated with reduced beige adipogenesis, a thermogenic and energy-dissipating function mediated by uncoupling protein-1 (UCP1)-expressing beige adipocytes. Here, we dissected an inflammation-driven inhibitory mechanism of beige adipogenesis in...

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Pubblicato in:Nat Immunol
Autori principali: Chung, Kyoung-Jin, Chatzigeorgiou, Antonios, Economopoulou, Matina, Garcia-Martin, Ruben, Alexaki, Vasileia I., Mitroulis, Ioannis, Nati, Marina, Gebler, Janine, Ziemssen, Tjalf, Goelz, Susan E., Phieler, Julia, Lim, Jong-Hyung, Karalis, Katia P., Papayannopoulou, Thalia, Bluher, Matthias, Hajishengallis, George, Chavakis, Triantafyllos
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436941/
https://ncbi.nlm.nih.gov/pubmed/28414311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3728
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