Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model

Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a potent inhibitor of matrix metalloproteinases (MMPs) is a common negative target of oncogenic signals and a potential therapeutic target for novel drug development. Here, we show that sequential RECKlessness stimulates angiogenesis...

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Vydáno v:Sci Rep
Hlavní autoři: Kowshik, Jaganathan, Mishra, Rajakishore, Sophia, Josephraj, Rautray, Satabdi, Anbarasu, Kumaraswamy, Reddy, G. Deepak, Dixit, Madhulika, Mahalingam, Sundarasamy, Nagini, Siddavaram
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435722/
https://ncbi.nlm.nih.gov/pubmed/28515436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01960-5
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