Functional interaction between FUS and SMN underlies SMA-like splicing changes in wild-type hFUS mice

Several of the identified genetic factors in Amyotrophic Lateral Sclerosis (ALS) point to dysfunction in RNA processing as a major pathogenic mechanism. However, whether a precise RNA pathway is particularly affected remains unknown. Evidence suggests that FUS, that is mutated in familial ALS, and S...

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Udgivet i:Sci Rep
Main Authors: Mirra, Alessia, Rossi, Simona, Scaricamazza, Silvia, Di Salvio, Michela, Salvatori, Illari, Valle, Cristiana, Rusmini, Paola, Poletti, Angelo, Cestra, Gianluca, Carrì, Maria Teresa, Cozzolino, Mauro
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435706/
https://ncbi.nlm.nih.gov/pubmed/28515487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02195-0
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