In vitro biomimetic platforms featuring a perfusion system and 3D spheroid culture promote the construction of tissue-engineered corneal endothelial layers

Corneal endothelial cells (CECs) are very important for the maintenance of corneal transparency. However, in vitro, CECs display limited proliferation and loss of phenotype via endothelial to mesenchymal transformation (EMT) and cellular senescence. In this study, we demonstrate that continuous supp...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Li, Shanyi, Han, Yuting, Lei, Hao, Zeng, Yingxin, Cui, Zekai, Zeng, Qiaolang, Zhu, Deliang, Lian, Ruiling, Zhang, Jun, Chen, Zhe, Chen, Jiansu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5429708/
https://ncbi.nlm.nih.gov/pubmed/28396609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00914-1
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