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Pentameric ligand-gated ion channels exhibit distinct transmembrane domain archetypes for folding/expression and function
Although transmembrane helix-helix interactions must be strong enough to drive folding, they must still permit the inter-helix movements associated with conformational change. Interactions between the outermost M4 and adjacent M1 and M3 α-helices of pentameric ligand-gated ion channels have been imp...
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| Опубликовано в: : | Sci Rep |
|---|---|
| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5428567/ https://ncbi.nlm.nih.gov/pubmed/28348412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00573-2 |
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