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Embracing Biological and Methodological Variance in a New Approach to Pre-Clinical Stroke Testing

High-profile failures in stroke clinical trials have discouraged clinical translation of neuroprotectants. While there are several plausible explanations for these failures, we believe that the fundamental problem is the way clinical and pre-clinical studies are designed and analyzed for heterogeneo...

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Détails bibliographiques
Publié dans:Transl Stroke Res
Auteurs principaux: Kent, Thomas A., Mandava, Pitchaiah
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425098/
https://ncbi.nlm.nih.gov/pubmed/27018014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12975-016-0463-9
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