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Embracing Biological and Methodological Variance in a New Approach to Pre-Clinical Stroke Testing

High-profile failures in stroke clinical trials have discouraged clinical translation of neuroprotectants. While there are several plausible explanations for these failures, we believe that the fundamental problem is the way clinical and pre-clinical studies are designed and analyzed for heterogeneo...

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Bibliographische Detailangaben
Veröffentlicht in:Transl Stroke Res
Hauptverfasser: Kent, Thomas A., Mandava, Pitchaiah
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5425098/
https://ncbi.nlm.nih.gov/pubmed/27018014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12975-016-0463-9
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