Non‐canonical WNT5A signaling up‐regulates the expression of the tumor suppressor 15‐PGDH and induces differentiation of colon cancer cells

The tumor suppressor 15‐hydroxyprostaglandin dehydrogenase (15‐PGDH) is the key enzyme in prostaglandin E2 catabolism and is down‐regulated in colorectal cancer (CRC) tissue. Canonical Wnt signaling is frequently elevated in colon cancers and has been shown to down‐regulate 15‐PGDH expression. There...

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Bibliografiske detaljer
Udgivet i:Mol Oncol
Main Authors: Mehdawi, Lubna M., Prasad, Chandra Prakash, Ehrnström, Roy, Andersson, Tommy, Sjölander, Anita
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2016
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423213/
https://ncbi.nlm.nih.gov/pubmed/27522468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.07.011
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