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Non‐canonical WNT5A signaling up‐regulates the expression of the tumor suppressor 15‐PGDH and induces differentiation of colon cancer cells

The tumor suppressor 15‐hydroxyprostaglandin dehydrogenase (15‐PGDH) is the key enzyme in prostaglandin E2 catabolism and is down‐regulated in colorectal cancer (CRC) tissue. Canonical Wnt signaling is frequently elevated in colon cancers and has been shown to down‐regulate 15‐PGDH expression. There...

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Detaylı Bibliyografya
Yayımlandı:Mol Oncol
Asıl Yazarlar: Mehdawi, Lubna M., Prasad, Chandra Prakash, Ehrnström, Roy, Andersson, Tommy, Sjölander, Anita
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2016
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423213/
https://ncbi.nlm.nih.gov/pubmed/27522468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.07.011
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