Defining the crucial domain and amino acid residues in bacterial Lon protease for DNA binding and processing of DNA-interacting substrates

Lon protease previously has been shown to interact with DNA, but the role of this interaction for Lon proteolytic activity has not been characterized. In this study, we used truncated Escherichia coli Lon constructs, bioinformatics analysis, and site-directed mutagenesis to identify Lon domains and...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Karlowicz, Anna, Wegrzyn, Katarzyna, Gross, Marta, Kaczynska, Dagmara, Ropelewska, Malgorzata, Siemiątkowska, Małgorzata, Bujnicki, Janusz M., Konieczny, Igor
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2017
Soggetti:
Protein Synthesis and Degradation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418049/
https://ncbi.nlm.nih.gov/pubmed/28292931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.766709
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