Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma

Cancer cells preferentially utilize glucose and glutamine, which provide macromolecules and antioxidants that sustain rapid cell division. Metabolic reprogramming in cancer drives an increased glycolytic rate that supports maximal production of these nutrients. The folate cycle, through transfer of...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Lee, Derek, Xu, Iris Ming-Jing, Chiu, David Kung-Chun, Lai, Robin Kit-Ho, Tse, Aki Pui-Wah, Lan Li, Lynna, Law, Cheuk-Ting, Tsang, Felice Ho-Ching, Wei, Larry Lai, Chan, Cerise Yuen-Ki, Wong, Chun-Ming, Ng, Irene Oi-Lin, Wong, Carmen Chak-Lui
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409797/
https://ncbi.nlm.nih.gov/pubmed/28394261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90253
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