Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription

Worldwide epidemics of metabolic diseases, including liver steatosis, are associated with an increased frequency of malignancies, showing the highest positive correlation for liver cancer. The heterogeneity of liver cancer represents a clinical challenge. In liver, the transcription factor PPARγ pro...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Patitucci, Cecilia, Couchy, Gabrielle, Bagattin, Alessia, Cañeque, Tatiana, de Reyniès, Aurélien, Scoazec, Jean-Yves, Rodriguez, Raphaël, Pontoglio, Marco, Zucman-Rossi, Jessica, Pende, Mario, Panasyuk, Ganna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409083/
https://ncbi.nlm.nih.gov/pubmed/28394260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI90327
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