Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC

Background: The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non–small cell lung cancer (NSCLC) is limited by adaptive activation of cell survival signals. We hypothesized that both signal transducer and activator of transcription 3 (STAT3) and...

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Veröffentlicht in:J Natl Cancer Inst
Hauptverfasser: Chaib, Imane, Karachaliou, Niki, Pilotto, Sara, Codony Servat, Jordi, Cai, Xueting, Li, Xuefei, Drozdowskyj, Ana, Servat, Carles Codony, Yang, Jie, Hu, Chunping, Cardona, Andres Felipe, Vivanco, Guillermo Lopez, Vergnenegre, Alain, Sanchez, Jose Miguel, Provencio, Mariano, Reguart, Noemi, Zhou, Caicun, Cao, Peng, Ma, Patrick C., Bivona, Trever G., Rosell, Rafael, Servat, Jordi Codony, de Marinis, Filippo, Passaro, Antonio, Carcereny, Enric, Campelo, Charo Garcia, Teixido, Cristina, Sperduti, Isabella, Rodriguez, Sonia, Lazzari, Chiara, Verlicchi, Alberto, de Aguirre, Itziar, Queralt, Cristina, Wei, Jia, Estrada, Roger, de la Bellacasa, Raimon Puig, Ramirez, Jose Luis, Jacobsen, Kirstine, Ditzel, Henrik J., Santarpia, Mariacarmela, Viteri, Santiago, Molina, Miguel Angel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409000/
https://ncbi.nlm.nih.gov/pubmed/28376152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djx014
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