Repurposing Mebendazole as a Replacement for Vincristine for the Treatment of Brain Tumors

The microtubule inhibitor vincristine is currently used to treat a variety of brain tumors, including low-grade glioma and anaplastic oligodendroglioma. Vincristine, however, does not penetrate well into brain tumor tissue, and moreover, it displays dose-limiting toxicities, including peripheral neu...

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Bibliographic Details
Published in:Mol Med
Main Authors: De Witt, Michelle, Gamble, Alexander, Hanson, Derek, Markowitz, Daniel, Powell, Caitlin, Al Dimassi, Saleh, Atlas, Mark, Boockvar, John, Ruggieri, Rosamaria, Symons, Marc
Format: Artigo
Language:Inglês
Published: Feinstein Institute for Medical Research 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5403762/
https://ncbi.nlm.nih.gov/pubmed/28386621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2017.00011
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