Drp1-dependent mitophagy protects against cisplatin-induced apoptosis of renal tubular epithelial cells by improving mitochondrial function

Cisplatin chemotherapy often causes acute kidney injury (AKI) in cancer patients. There is increasing evidence that mitochondrial dysfunction plays an important role in cisplatin-induced nephrotoxicity. Degradation of damaged mitochondria is carried out by mitophagy. Although mitophagy is considered...

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Udgivet i:Oncotarget
Main Authors: Zhao, Chuanyan, Chen, Zhuyun, Qi, Jia, Duan, Suyan, Huang, Zhimin, Zhang, Chengning, Wu, Lin, Zeng, Ming, Zhang, Bo, Wang, Ningning, Mao, Huijuan, Zhang, Aihua, Xing, Changying, Yuan, Yanggang
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400560/
https://ncbi.nlm.nih.gov/pubmed/28423497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15470
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