Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma

Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise in young children and are not surgically resectable. These tumors are characterized by a high rate of histone H3 mutation, resulting in repla...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Huang, Tina Y., Piunti, Andrea, Lulla, Rishi R., Qi, Jin, Horbinski, Craig M., Tomita, Tadanori, James, C. David, Shilatifard, Ali, Saratsis, Amanda M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5392913/
https://ncbi.nlm.nih.gov/pubmed/28416018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0436-6
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