Coordinate activities of BRD4 and CDK9 in the transcriptional elongation complex are required for TGFβ-induced Nox4 expression and myofibroblast transdifferentiation

Transdifferentiation of quiescent dermal fibroblasts to secretory myofibroblasts has a central role in wound healing and pathological scar formation. This myofibroblast transdifferentiation process involves TGFβ-induced de novo synthesis of alpha smooth muscle cell actin (αSMA)+ fibers that enhance...

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Bibliografische gegevens
Gepubliceerd in:Cell Death Dis
Hoofdauteurs: Ijaz, Talha, Jamaluddin, Mohammad, Zhao, Yingxin, Zhang, Yueqing, Jay, Jayson, Finnerty, Celeste C, Herndon, David N, Tilton, Ronald G, Brasier, Allan R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5386453/
https://ncbi.nlm.nih.gov/pubmed/28182006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.434
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