Are polymorphisms of the immunoregulatory factor CD40LG implicated in acute transfusion reactions?

The CD40 ligand (CD40L/CD154), a member of TNF superfamily, is notably expressed on activated CD4+ T-cells and stimulated platelets. CD40L is linked to a variety of pathologies and to acute transfusion reactions (ATR). Mutations in this gene (CD40LG) lead to X-linked hyper-IgM syndrome. Some CD40LG...

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Udgivet i:Sci Rep
Main Authors: Aloui, Chaker, Sut, Caroline, Prigent, Antoine, Fagan, Jocelyne, Cognasse, Fabrice, Granados-Herbepin, Viviana, Touraine, Renaud, Pozzetto, Bruno, Aouni, Mahjoub, Fendri, Chedlia, Hassine, Mohsen, Chakroun, Tahar, Jemni-Yacoub, Saloua, Garraud, Olivier, Laradi, Sandrine
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5384113/
https://ncbi.nlm.nih.gov/pubmed/25430087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07239
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