A Common Genetic Variant Risk Score Is Associated with Drug-Induced QT Prolongation and Torsade de Pointes Risk: a Pilot Study

BACKGROUND: Drug-induced QT interval prolongation, a risk factor for life-threatening ventricular arrhythmias, is a potential side effect of many marketed and withdrawn medications. The contribution of common genetic variants previously associated with baseline QT interval to drug-induced QT prolong...

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Publicat a:Circulation
Autors principals: Strauss, David G., Vicente, Jose, Johannesen, Lars, Blinova, Ksenia, Mason, Jay W., Weeke, Peter, Behr, Elijah R., Roden, Dan, Woosley, Ray, Kosova, Gulum, Rosenberg, Michael A., Newton-Cheh, Christopher
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5380476/
https://ncbi.nlm.nih.gov/pubmed/28213480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.116.023980
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