Unique spectral signatures of the nucleic acid dye acridine orange can distinguish cell death by apoptosis and necroptosis

Cellular injury and death are ubiquitous features of disease, yet tools to detect them are limited and insensitive to subtle pathological changes. Acridine orange (AO), a nucleic acid dye with unique spectral properties, enables real-time measurement of RNA and DNA as proxies for cell viability duri...

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發表在:J Cell Biol
Main Authors: Plemel, Jason R., Caprariello, Andrew V., Keough, Michael B., Henry, Tyler J., Tsutsui, Shigeki, Chu, Tak H., Schenk, Geert J., Klaver, Roel, Yong, V. Wee, Stys, Peter K.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2017
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Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5379938/
https://ncbi.nlm.nih.gov/pubmed/28264914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201602028
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