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Racemic hemiacetals as oxygen-centered pronucleophiles triggering cascade 1,4-addition/Michael reaction through dynamic kinetic resolution under iminium catalysis. Development and mechanistic insights

2-Hydroxydihydropyran-5-ones behave as excellent polyfunctional reagents able to react with enals through oxa-Michael/Michael process cascade under the combination of iminium and enamine catalysis. These racemic hemiacetalic compounds are used as unconventional O-pronucleophiles in the initial oxa-M...

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Vydáno v:Chem Sci
Hlavní autoři: Orue, Ane, Uria, Uxue, Roca-López, David, Delso, Ignacio, Reyes, Efraím, Carrillo, Luisa, Merino, Pedro, Vicario, Jose L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Royal Society of Chemistry 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376714/
https://ncbi.nlm.nih.gov/pubmed/28451356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc00009j
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