A whole-body physiologically based pharmacokinetic (WB-PBPK) model of ciprofloxacin: a step towards predicting bacterial killing at sites of infection

The purpose of this study was to develop a whole-body physiologically based pharmacokinetic (WB-PBPK) model for ciprofloxacin for ICU patients, based on only plasma concentration data. In a next step, tissue and organ concentration time profiles in patients were predicted using the developed model....

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Publicat a:J Pharmacokinet Pharmacodyn
Autors principals: Sadiq, Muhammad W., Nielsen, Elisabet I., Khachman, Dalia, Conil, Jean-Marie, Georges, Bernard, Houin, Georges, Laffont, Celine M., Karlsson, Mats O., Friberg, Lena E.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2016
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5376394/
https://ncbi.nlm.nih.gov/pubmed/27578330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-016-9486-9
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