Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease

Huntington’s disease (HD) is a polyglutamine (polyQ) disease caused by aberrant expansion of the polyQ tract in Huntingtin (HTT). While motor impairment mediated by polyQ-expanded HTT has been intensively studied, molecular mechanisms for nonmotor symptoms in HD, such as psychiatric manifestations,...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Tanaka, Motomasa, Ishizuka, Koko, Nekooki-Machida, Yoko, Endo, Ryo, Takashima, Noriko, Sasaki, Hideyuki, Komi, Yusuke, Gathercole, Amy, Huston, Elaine, Ishii, Kazuhiro, Hui, Kelvin Kai-Wan, Kurosawa, Masaru, Kim, Sun-Hong, Nukina, Nobuyuki, Takimoto, Eiki, Houslay, Miles D., Sawa, Akira
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5373889/
https://ncbi.nlm.nih.gov/pubmed/28263187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85594
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