HuangQin Decoction Attenuates CPT-11-Induced Gastrointestinal Toxicity by Regulating Bile Acids Metabolism Homeostasis

Irinotecan (CPT-11) is a potent chemotherapeutic agent, however, its clinical usage is often limited by the induction of severe gastrointestinal (GI) toxicity, especially late-onset diarrhea. HuangQin Decoction (HQD), commonly used for the treatment of GI ailments, has been proved could significantl...

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Bibliographische Detailangaben
Veröffentlicht in:Front Pharmacol
Hauptverfasser: Wang, Xu, Cui, Dong-ni, Dai, Xiao-min, Wang, Jing, Zhang, Wei, Zhang, Zun-jian, Xu, Feng-guo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5371663/
https://ncbi.nlm.nih.gov/pubmed/28424615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00156
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