Phakellistatins: An Underwater Unsolved Puzzle

A critical summary on the discovery of the nineteen members of the phakellistatin family (phakellistatin 1–19), cytotoxic proline-rich cyclopeptides of marine origin, is reported. Isolation, structural elucidation, and biological properties of the various-sized natural macrocycles are described, alo...

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Bibliographic Details
Published in:Mar Drugs
Main Authors: Meli, Alessandra, Tedesco, Consiglia, Della Sala, Giorgio, Schettini, Rosaria, Albericio, Fernando, De Riccardis, Francesco, Izzo, Irene
Format: Artigo
Language:Inglês
Published: MDPI 2017
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5367035/
https://ncbi.nlm.nih.gov/pubmed/28335479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md15030078
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