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An epigenetic modifier induces production of (10′S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla
Incorporation of the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), to a culture broth of the endophytic fungus Phoma sp. nov. LG0217 isolated from Parkinsonia microphylla changed its metabolite profile and resulted in the production of (10′S)-verruculide B (1), vermis...
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發表在: | Bioorg Med Chem |
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Main Authors: | , , , , , , |
格式: | Artigo |
語言: | Inglês |
出版: |
2017
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主題: | |
在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5362119/ https://ncbi.nlm.nih.gov/pubmed/28202316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.01.048 |
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