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An epigenetic modifier induces production of (10′S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla

Incorporation of the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), to a culture broth of the endophytic fungus Phoma sp. nov. LG0217 isolated from Parkinsonia microphylla changed its metabolite profile and resulted in the production of (10′S)-verruculide B (1), vermis...

詳細記述

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書誌詳細
出版年:Bioorg Med Chem
主要な著者: Gubiani, Juliana R., Kithsiri Wijeratne, E. M., Shi, Taoda, Araujo, Angela R., Arnold, A. Elizabeth, Chapman, Eli, Leslie Gunatilaka, A. A.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362119/
https://ncbi.nlm.nih.gov/pubmed/28202316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.01.048
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