An epigenetic modifier induces production of (10′S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla

Incorporation of the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), to a culture broth of the endophytic fungus Phoma sp. nov. LG0217 isolated from Parkinsonia microphylla changed its metabolite profile and resulted in the production of (10′S)-verruculide B (1), vermis...

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Publicado en:Bioorg Med Chem
Autores principales: Gubiani, Juliana R., Kithsiri Wijeratne, E. M., Shi, Taoda, Araujo, Angela R., Arnold, A. Elizabeth, Chapman, Eli, Leslie Gunatilaka, A. A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362119/
https://ncbi.nlm.nih.gov/pubmed/28202316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.01.048
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