VE-cadherin RGD motifs promote metastasis and constitute a potential therapeutic target in melanoma and breast cancers

We have investigated the role of vascular-endothelial (VE)-cadherin in melanoma and breast cancer metastasis. We found that VE-cadherin is expressed in highly aggressive melanoma and breast cancer cell lines. Remarkably, inactivation of VE-cadherin triggered a significant loss of malignant traits (p...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Bartolomé, Rubén A., Torres, Sofía, de Val, Soledad Isern, Escudero-Paniagua, Beatriz, Calviño, Eva, Teixidó, Joaquín, Casal, J. Ignacio
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352113/
https://ncbi.nlm.nih.gov/pubmed/27966446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13832
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