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E4 Ligase Specific Ubiquitylation Hubs Coordinate DNA Double Strand Break Repair and Apoptosis

The repair of DNA double strand breaks (DSBs) requires tight regulation with the DNA damage response that mediates apoptotic death of damaged cells. Multiple protein ubiquitylation events at the sites of DSBs regulate damage recognition, repair, and signalling processes. However, the spatiotemporal...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Struct Mol Biol
Prif Awduron: Ackermann, Leena, Schell, Michael, Pokrzywa, Wojciech, Kevei, Éva, Gartner, Anton, Schumacher, Björn, Hoppe, Thorsten
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349472/
https://ncbi.nlm.nih.gov/pubmed/27669035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3296
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