Safety and Efficacy of a Topical Sodium Channel Inhibitor (TV-45070) in Patients With Postherpetic Neuralgia (PHN): A Randomized, Controlled, Proof-of-Concept, Crossover Study, With a Subgroup Analysis of the Nav1.7 R1150W Genotype

OBJECTIVE: The objective was to evaluate the safety and efficacy of TV-45070 ointment, as a treatment for postherpetic neuralgia, and to explore the response in patients with the Nav1.7 R1150W gain-of-function polymorphism. MATERIALS AND METHODS: This was a randomized, placebo-controlled, 2-period,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Clin J Pain
Prif Awduron: Price, Nicola, Namdari, Rostam, Neville, Judith, Proctor, Katie J.W., Kaber, Samer, Vest, Jeffery, Fetell, Michael, Malamut, Richard, Sherrington, Robin P., Pimstone, Simon N., Goldberg, Yigal P.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Lippincott Williams & Wilkins 2017
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348105/
https://ncbi.nlm.nih.gov/pubmed/28266963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/AJP.0000000000000408
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