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A new Caenorhabditis elegans model of human huntingtin 513 aggregation and toxicity in body wall muscles

Expanded polyglutamine repeats in different proteins are the known determinants of at least nine progressive neurodegenerative disorders whose symptoms include cognitive and motor impairment that worsen as patients age. One such disorder is Huntington’s Disease (HD) that is caused by a polyglutamine...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Lee, Amy L., Ung, Hailey M., Sands, L. Paul, Kikis, Elise A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5345860/
https://ncbi.nlm.nih.gov/pubmed/28282438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173644
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