Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability

The moderate anticancer effect of arginine deprivation in clinical trials has been linked to an induced argininosuccinate synthetase (ASS1) expression in initially ASS1-negative tumors, and ASS1-positive cancers are anticipated as non-responders. Our previous studies indicated that arginine deprivat...

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Udgivet i:Oncotarget
Main Authors: Kurlishchuk, Yuliya, Vynnytska-Myronovska, Bozhena, Grosse-Gehling, Philipp, Bobak, Yaroslav, Manig, Friederike, Chen, Oleg, Merker, Sebastian R., Henle, Thomas, Löck, Steffen, Stange, Daniel E., Stasyk, Oleh, Kunz, Leoni A.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341980/
https://ncbi.nlm.nih.gov/pubmed/27689335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12320
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