Deletion of IQGAP1 promotes Helicobacter pylori-induced gastric dysplasia in mice and acquisition of cancer stem cell properties in vitro

Helicobacter pylori infection is responsible for gastric carcinogenesis but host factors are also implicated. IQGAP1, a scaffolding protein of the adherens junctions interacting with E-cadherin, regulates cellular plasticity and proliferation. In mice, IQGAP1 deficiency leads to gastric hyperplasia....

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Veröffentlicht in:Oncotarget
Hauptverfasser: Bessède, Emilie, Molina, Silvia, Amador, Luis Acuña, Dubus, Pierre, Staedel, Cathy, Chambonnier, Lucie, Buissonnière, Alice, Sifré, Elodie, Giese, Alban, Bénéjat, Lucie, Rousseau, Benoît, Costet, Pierre, Sacks, David B., Mégraud, Francis, Varon, Christine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5340252/
https://ncbi.nlm.nih.gov/pubmed/27729612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12486
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