Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6

BACKGROUND: Cancer cells are known to over-express TRAF6 that is critical for both AKT and TAK1 activations. The Really Interesting New Gene (RING) domain of TRAF6 is believed to be responsible for the E3 ligase activity, ZINC fingers of TRAF6 provide critical support for the activity of the RING do...

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Podrobná bibliografie
Vydáno v:J Exp Clin Cancer Res
Hlavní autoři: Qi, Yonghao, Pradipta, Ambara R., Li, Miao, Zhao, Xuan, Lu, Lulu, Fu, Xuegang, Wei, Jing, Hsung, Richard P., Tanaka, Katsunori, Zhou, Lijun
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324264/
https://ncbi.nlm.nih.gov/pubmed/28231796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0502-8
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