Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6

BACKGROUND: Cancer cells are known to over-express TRAF6 that is critical for both AKT and TAK1 activations. The Really Interesting New Gene (RING) domain of TRAF6 is believed to be responsible for the E3 ligase activity, ZINC fingers of TRAF6 provide critical support for the activity of the RING do...

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Publicat a:J Exp Clin Cancer Res
Autors principals: Qi, Yonghao, Pradipta, Ambara R., Li, Miao, Zhao, Xuan, Lu, Lulu, Fu, Xuegang, Wei, Jing, Hsung, Richard P., Tanaka, Katsunori, Zhou, Lijun
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5324264/
https://ncbi.nlm.nih.gov/pubmed/28231796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-017-0502-8
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